Journal: Antimicrobial Agents and Chemotherapy
Article Title: In Vitro and In Vivo Characterization of Tebipenem, an Oral Carbapenem
doi: 10.1128/AAC.02240-19
Figure Lengend Snippet: Impact of human, mouse serum on tebipenem, meropenem MIC
Article Snippet: Effect of varying the pH on antibacterial activity of tebipenem in media and pooled human urine table ft1 table-wrap mode="anchored" t5 TABLE 5 caption a7 Organism ESBL Compound CAMHB MIC (μg/ml) (fold vs CAMHB) a 50% human serum 10% human serum 50% mouse serum 10% mouse serum E. coli ATCC 25922 N Tebipenem 0.15 0.03 (2) 0.03 (2) 0.5 (32) 0.06 (4) Meropenem 0.015 0.03 (2) 0.03 (2) 0.03 (2) 0.03 (2) E. coli ATCC 35218 Y Tebipenem 0.15 0.03 (2) 0.03 (2) 0.5 (32) 0.03 (2) Meropenem 0.015 0.03 (2) 0.03 (2) 0.03 (2) 0.015 (0) K. pneumoniae ATCC 43816 N Tebipenem 0.03 0.06 (2) 0.03 (0) 1 (32) 0.06 (2) Meropenem 0.03 0.03 (0) 0.03 (0) 0.03 (0) 0.03 (0) K. pneumoniae ATCC 700603 Y Tebipenem 0.06 0.12 (2) 0.06 (0) 2 (32) 0.12 (2) Meropenem 0.03 0.06 (2) 0.03 (0) 0.12 (4) 0.03 (0) P. mirabilis ATCC 43071 N Tebipenem 0.12 0.25 (2) 0.25 (2) 2 (16) 0.25 (2) Meropenem 0.06 0.12 (2) 0.12 (2) 0.06 (0) 0.06 (0) P. mirabilis MMX 6343 Y Tebipenem 0.5 0.5 (0) 1 (2) 4 (8) 1 (2) Meropenem 0.12 0.12 (0) 0.12 (0) 0.25 (2) 0.5 (4) Open in a separate window a Bold indicates >4× differences from standard conditions (CAMHB minus serum).
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